TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)

Mutations in TNFRSF1A encoding TNF receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder. Misfolding, intracellular aggregation, and ligand-independent signaling by mutant TNFR1 are central to disease pathophysiology. Our aim was to understand the extent of signaling pathway perturbation in TRAPS. A prototypic mut...

Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNF -Mediated NF- B Activation

of TNFR1 leads to the recruitment of the death domain (DD)-containing adaptor molecule TNFR1-associated death domain protein (TRADD), which serves as a platDaniel F. Legler,1,2,* Olivier Micheau,1 Marie-Agnès Doucey,1 Jürg Tschopp,1 and Claude Bron1 form to recruit additional mediators (Hsu et al., 1995, Institute of Biochemistry 1996). TRADD, in turn, binds the DD-containing Ser/ University of...

Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism.

Tumor necrosis factor (TNF) and epidermal growth factor (EGF) are key regulators in the intricate balance maintaining intestinal homeostasis. Previous work from our laboratory shows that TNF attenuates ligand-driven EGF receptor (EGFR) phosphorylation in intestinal epithelial cells. To identify the mechanisms underlying this effect, we examined EGFR phosphorylation in cells lacking individual T...

BAFF Receptor by TNF Key Molecular Contacts Promote Recognition

Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis.

TNF is essential for the development of glomerulonephritis, an immune-mediated disorder that is a major cause of renal failure worldwide. However, TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. TNFR1-deficient mice subjected to immune complex-mediated glomerulonephritis developed less proteinuria and glom...